Hydrogen Bonding Contribution to Lipophilicity Parameters. Hydrogen Acceptor and Hydrogen Acceptor Donor Parameters

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Title:Hydrogen Bonding Contribution to Lipophilicity Parameters. Hydrogen Acceptor and Hydrogen Acceptor Donor Parameters
Creators:
Charton, Marvin
Charton, Barbara I.
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 69, 12, pp. 2147-2173
Uncontrolled Keywords:Partition coefficient, Lipophilicity, Intermolecular force model, Substituent effects, Hydrogen bonds

Abstract

In our analysis of the composition of lipophilicity parameters by the intermolecular force (IMF) model we have made use of <i>n</i><sub>H</sub>, the number of OH and/or NH bonds, as a measure of the hydrogen donor capacity of a substituent; and <i>n</i><sub>n</sub>, the number of lone pairs on O and/or N atoms in the substituent, as a measure of the hydrogen acceptor capacity of the substituent. The basis of this method is the reasonable assumption that in 55.6 molar water hydrogen bonding is maximized. The method does not account however for differences in the energy of different types of hydrogen bonds, but further assumes that these differences are to a first approximation negligible. In order to improve the model we have defined a scale of group hydrogen bonding acceptor parameters, η<sub>XHA</sub>, and overall hydrogen bond parameters η<sub>XHAD</sub> from the water/1-octanol partition coefficients of AkX where Ak is alkyl. These parameters should account for both the extent of hydrogen bonding in water and for the difference in hydrogen bond energies of the various types of hydrogen bonds encountered. Correlations of log <i>P</i> values for Ph(CH<sub>2</sub>)<i><sub>n</sub></i>X, X<sup>1</sup>(CH<sub>2</sub>)X<sup>2</sup>, and substituted amino acids Xaa with the IMF equation using the η<sub>XHA</sub> and η<sub>XHAD</sub> parameters demonstrated their use. Correlation of log <i>P</i> values for PhX suggested that for many groups separate sets of η<sub>XHA</sub> and η<sub>XHAD</sub> values are required when they are bonded to sp<sup>2</sup> hybridized carbon rather than sp<sup>3</sup> hybridized carbon. <p>

Title:Hydrogen Bonding Contribution to Lipophilicity Parameters. Hydrogen Acceptor and Hydrogen Acceptor Donor Parameters
Creators:
Charton, Marvin
Charton, Barbara I.
Uncontrolled Keywords:Partition coefficient, Lipophilicity, Intermolecular force model, Substituent effects, Hydrogen bonds
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:69
Number:12
Page Range:pp. 2147-2173
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20042147UNSPECIFIED
ID Code:2327
Item Type:Article
Deposited On:06 Feb 2009 17:17
Last Modified:06 Feb 2009 16:17

Citation

Charton, Marvin; Charton, Barbara I. (2004) Hydrogen Bonding Contribution to Lipophilicity Parameters. Hydrogen Acceptor and Hydrogen Acceptor Donor Parameters. Collection of Czechoslovak Chemical Communications, 69 (12). pp. 2147-2173. ISSN 0010-0765

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