Voltammetric Determination of Mitomycin c Using a Chemically-Modified Glassy Carbon Electrode

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Title:Voltammetric Determination of Mitomycin c Using a Chemically-Modified Glassy Carbon Electrode
Creators:
Qu, Wanyun
Wang, Hong
Wu, Kangbing
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 70, 2, pp. 178-187
Uncontrolled Keywords:Antitumor agents, Electrooxidation, Electrochemistry, Carbon nanotube, Analytical methods, DNA binding molecules, Voltammetry, Chemically modified electrode, Mitomycin c

Abstract

An electrochemical method for the direct determination of mitomycin c (MMC), based on a multi wall carbon nanotube (MWNT)-modified electrode, has been developed. A well-shaped and highly sensitive oxidation peak at 0.79 V was observed on the MWNT-modified electrode for MMC. Further studies show strong evidence that MWNT-modified electrode significantly enhances the sensitivity of determination of MMC since the oxidation peak current of MMC increases remarkably, compared with that with a bare glassy carbon electrode. All the experimental parameters such as pH, scan rate, accumulation conditions, have been examined. A sensitive linear voltammetric response for MMC was obtained over the concentration range of 2.5 × 10<sup>-7</sup>-1.0 × 10<sup>-4</sup> mol/l; the detection limit is 8 × 10<sup>-8</sup> mol/l. Compared with other methods, this new-proposed method possesses advantages such as high sensitivity, fast response, low cost and simplicity. Eventually, the proposed method has been successfully employed to detect MMC in urine samples. <p>

Title:Voltammetric Determination of Mitomycin c Using a Chemically-Modified Glassy Carbon Electrode
Creators:
Qu, Wanyun
Wang, Hong
Wu, Kangbing
Uncontrolled Keywords:Antitumor agents, Electrooxidation, Electrochemistry, Carbon nanotube, Analytical methods, DNA binding molecules, Voltammetry, Chemically modified electrode, Mitomycin c
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:70
Number:2
Page Range:pp. 178-187
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20050178UNSPECIFIED
ID Code:2351
Item Type:Article
Deposited On:06 Feb 2009 17:17
Last Modified:06 Feb 2009 16:17

Citation

Qu, Wanyun; Wang, Hong; Wu, Kangbing (2005) Voltammetric Determination of Mitomycin c Using a Chemically-Modified Glassy Carbon Electrode. Collection of Czechoslovak Chemical Communications, 70 (2). pp. 178-187. ISSN 0010-0765

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