Cathodic Stripping Voltammetry of 2-Thiouracils

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Title:Cathodic Stripping Voltammetry of 2-Thiouracils
Creators:
Kasprzak, Michał
Ciesielski, Witold
Skrzypek, Sławomira
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 70, 2, pp. 188-197
Uncontrolled Keywords:Thiouracils, Pyrimidines, Differential pulse cathodic stripping voltammetry, Electrochemistry, Antithyroid drugs, Nucleobases, Electrochemical determination

Abstract

Four 6-R-2-thiouracils (R = H, methyl, propyl, benzyl) were examined by differential pulse cathodic stripping voltammetry on mercury electrode. The research led to a very sensitive analytical method that allows their determination on nanomolar level. The detection limit of the 6-propyl derivative is as low as 1.0 × 10<sup>-9</sup> mol dm<sup>-3</sup>. The procedure is very simple and utilizes only most common chemical reagents (such as acetate buffer). The buffer concentration plays an important role in the preconcentration stage, due to the adsorption processes accompanying electrode reactions. The new analytical method was tested with commercial samples of various antithyroid drugs. <p>

Title:Cathodic Stripping Voltammetry of 2-Thiouracils
Creators:
Kasprzak, Michał
Ciesielski, Witold
Skrzypek, Sławomira
Uncontrolled Keywords:Thiouracils, Pyrimidines, Differential pulse cathodic stripping voltammetry, Electrochemistry, Antithyroid drugs, Nucleobases, Electrochemical determination
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:70
Number:2
Page Range:pp. 188-197
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20050188UNSPECIFIED
ID Code:2352
Item Type:Article
Deposited On:06 Feb 2009 17:17
Last Modified:06 Feb 2009 16:18

Citation

Kasprzak, Michał; Ciesielski, Witold; Skrzypek, Sławomira (2005) Cathodic Stripping Voltammetry of 2-Thiouracils. Collection of Czechoslovak Chemical Communications, 70 (2). pp. 188-197. ISSN 0010-0765

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