Poly(ethylene glycol)-Based Polymer Carrier of Doxorubicin Degradable by Both Enzymatic and Chemical Hydrolyses

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Title:Poly(ethylene glycol)-Based Polymer Carrier of Doxorubicin Degradable by Both Enzymatic and Chemical Hydrolyses
Creators:
Pechar, Michal
Braunová, Alena
Ulbrich, Karel
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 70, 3, pp. 327-338
Uncontrolled Keywords:Cancer therapy, Poly(ethylene glycol), Polymer-supported drugs, Peptide synthesis, Drug delivery systems, Antineoplastics, Doxorubicin, Cytostatics, Biodegradable polymers

Abstract

The synthesis and characterization of a water-soluble biodegradable multiblock polyurethane based on poly(ethylene glycol) blocks interconnected by a pentapeptide derivative <i>N</i>,<i>N'</i>-bis(aspartylprolyl)lysine is described. The pentapeptide linkages are susceptible both to chemical hydrolysis in neutral and mild acid medium (pH 5) and to enzymatic degradation by lysosomal enzyme cathepsin B. Anti-cancer drug doxorubicin was attached to a hydrazide derivative of the polymer via a hydrolytically labile hydrazone bond. Both the pH-triggered hydrolytic release of the drug and the degradation of the polymer carrier by enzymatic and chemical hydrolysis were studied using liquid chromatography. <p>

Title:Poly(ethylene glycol)-Based Polymer Carrier of Doxorubicin Degradable by Both Enzymatic and Chemical Hydrolyses
Creators:
Pechar, Michal
Braunová, Alena
Ulbrich, Karel
Uncontrolled Keywords:Cancer therapy, Poly(ethylene glycol), Polymer-supported drugs, Peptide synthesis, Drug delivery systems, Antineoplastics, Doxorubicin, Cytostatics, Biodegradable polymers
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:70
Number:3
Page Range:pp. 327-338
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20050327UNSPECIFIED
ID Code:2362
Item Type:Article
Deposited On:06 Feb 2009 17:18
Last Modified:06 Feb 2009 16:18

Citation

Pechar, Michal; Braunová, Alena; Ulbrich, Karel (2005) Poly(ethylene glycol)-Based Polymer Carrier of Doxorubicin Degradable by Both Enzymatic and Chemical Hydrolyses. Collection of Czechoslovak Chemical Communications, 70 (3). pp. 327-338. ISSN 0010-0765

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