Synthesis, Reactions, Conformation Analysis, and NMR Spectra of 5,10-Epoxy-5ξ,10ξ-estrane-3,17-diones

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Title:Synthesis, Reactions, Conformation Analysis, and NMR Spectra of 5,10-Epoxy-5ξ,10ξ-estrane-3,17-diones
Creators:
Buděšínský, Miloš
Fajkoš, Jan
Günter, Jaroslav
Kasal, Alexander
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 70, 4, pp. 507-518
Uncontrolled Keywords:Epoxide cleavage, Conformation analysis, Epoxidation, Steroids, Stereoselective reactions, NMR spectroscopy

Abstract

On epoxidation of estr-5(10)-ene-3,17-dione, the 5β,10β-epoxide is the major product. The mixture of epoxides was converted into 5,10β-dihydroxy-5α-estrane-3,17-dione, 10α- and 10β-hydroxyestr-4-ene-3,17-dione, and estrone. Due to the sensitivity of the products, <sup>1</sup>H&nbsp;NMR was the best way to monitor the reaction pathway. <p>

Title:Synthesis, Reactions, Conformation Analysis, and NMR Spectra of 5,10-Epoxy-5ξ,10ξ-estrane-3,17-diones
Creators:
Buděšínský, Miloš
Fajkoš, Jan
Günter, Jaroslav
Kasal, Alexander
Uncontrolled Keywords:Epoxide cleavage, Conformation analysis, Epoxidation, Steroids, Stereoselective reactions, NMR spectroscopy
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:70
Number:4
Page Range:pp. 507-518
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20050507UNSPECIFIED
ID Code:2375
Item Type:Article
Deposited On:06 Feb 2009 17:18
Last Modified:06 Feb 2009 16:18

Citation

Buděšínský, Miloš; Fajkoš, Jan; Günter, Jaroslav; Kasal, Alexander (2005) Synthesis, Reactions, Conformation Analysis, and NMR Spectra of 5,10-Epoxy-5ξ,10ξ-estrane-3,17-diones. Collection of Czechoslovak Chemical Communications, 70 (4). pp. 507-518. ISSN 0010-0765

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