The Site of Action of General Anesthetics - A Chemical Approach

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Title:The Site of Action of General Anesthetics - A Chemical Approach
Creators:
Sandorfy, Camille
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 70, 5, pp. 539-549
Uncontrolled Keywords:<i>Ab initio</i> calculations, Glycoproteins, Anesthesia, Glycoconjugates, Glycosphingolipids, Protein-carbohydrate interactions, Weak hydrogen bonds

Abstract

Recently Urban (<i>Br. J. Anaesth.</i> <strong>2002</strong>, <i>89</i>, 167) and Trudell (<i>Br. J. Anaesth.</i> <strong>2002</strong>, <i>89</i>, 32) assessed the present state of the art in anesthesiological research. This article is an attempt to add to the discussion some ideas from the chemist's point of view. General anesthesia is a matter of molecular associations. Among the intermolecular interactions that can be involved, weak hydrogen bonding and van der Waals forces are believed to be most important. A pluralistic view is proposed, thereby different anesthetics can choose different interactions in conformity with their chemical structure. This can involve proteins, lipids, and sugars. Special attention is given to glycoproteins and glycosphingolipids. A review with 90 references. <p>

Title:The Site of Action of General Anesthetics - A Chemical Approach
Creators:
Sandorfy, Camille
Uncontrolled Keywords:<i>Ab initio</i> calculations, Glycoproteins, Anesthesia, Glycoconjugates, Glycosphingolipids, Protein-carbohydrate interactions, Weak hydrogen bonds
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:70
Number:5
Page Range:pp. 539-549
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20050539UNSPECIFIED
ID Code:2377
Item Type:Article
Deposited On:06 Feb 2009 17:18
Last Modified:06 Feb 2009 16:18

Citation

Sandorfy, Camille (2005) The Site of Action of General Anesthetics - A Chemical Approach. Collection of Czechoslovak Chemical Communications, 70 (5). pp. 539-549. ISSN 0010-0765

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