Nucleophilic Substitution and Lipophilicity - Structure Relations in Methylazolopyridazines

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Title:Nucleophilic Substitution and Lipophilicity - Structure Relations in Methylazolopyridazines
Creators:
Katrusiak, Anna
Ratajczak-Sitarz, Małgorzata
Skierska, Urszula
Zinczenko, Wiktoria
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 70, 9, pp. 1372-1386
Uncontrolled Keywords:Lipophilicity, X-Ray diffraction, Azolopyridazines, Triazolopyridazines, Tetrazolopyridazines, Nitrogen heterocycles

Abstract

Syntheses of methyl[1,2,4]triazolo- or methyltetrazolopyridazine isomers, their separation and nucleophilic substitution with morpholine, dimethylamine and hydrazine have been described. The lipophilicity of the azolopyridazines has been measured and related to the number and sites of the methyl substituents. The structures of new methylated azolopyridazines have been characterized by <sup>1</sup>H NMR, MS spectra, and X-ray diffraction. <p>

Title:Nucleophilic Substitution and Lipophilicity - Structure Relations in Methylazolopyridazines
Creators:
Katrusiak, Anna
Ratajczak-Sitarz, Małgorzata
Skierska, Urszula
Zinczenko, Wiktoria
Uncontrolled Keywords:Lipophilicity, X-Ray diffraction, Azolopyridazines, Triazolopyridazines, Tetrazolopyridazines, Nitrogen heterocycles
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:70
Number:9
Page Range:pp. 1372-1386
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20051372UNSPECIFIED
ID Code:2417
Item Type:Article
Deposited On:06 Feb 2009 17:18
Last Modified:06 Feb 2009 16:18

Citation

Katrusiak, Anna; Ratajczak-Sitarz, Małgorzata; Skierska, Urszula; Zinczenko, Wiktoria (2005) Nucleophilic Substitution and Lipophilicity - Structure Relations in Methylazolopyridazines. Collection of Czechoslovak Chemical Communications, 70 (9). pp. 1372-1386. ISSN 0010-0765

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