Synthesis of Aminopropyl Phosphonate Nucleosides with Purine and Pyrimidine Bases

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Title:Synthesis of Aminopropyl Phosphonate Nucleosides with Purine and Pyrimidine Bases
Creators:
Zhou, Ding
Lagoja, Irene M.
Van Aerschot, Arthur
Herdewijn, Piet
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 71, 1, pp. 15-34
Uncontrolled Keywords:Acyclic nucleoside phosphonates, Mitsunobu reaction, Aminopropyl phosphonic acids, Acyclic nucleotide analogues, Antiviral activity

Abstract

The synthesis and antiviral evaluation of new acyclic phosphonate nucleosides related to HPMPC (Cidofovir) has been described. These aminopropyl phosphonate nucleosides <strong>1</strong>-<strong>3</strong> have an amino function within either the acyclic chain (series <strong>2</strong> and <strong>3</strong>) or as substituent (series <strong>1</strong>). Both purine and pyrimidine nucleotide analogues have been synthesized. In contrast to HPMPC the oxygen analogue of <strong>2c</strong>, only a weak antiherpes virus activity could be demonstrated for <strong>2b</strong> and <strong>2c</strong>. <p>

Title:Synthesis of Aminopropyl Phosphonate Nucleosides with Purine and Pyrimidine Bases
Creators:
Zhou, Ding
Lagoja, Irene M.
Van Aerschot, Arthur
Herdewijn, Piet
Uncontrolled Keywords:Acyclic nucleoside phosphonates, Mitsunobu reaction, Aminopropyl phosphonic acids, Acyclic nucleotide analogues, Antiviral activity
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:71
Number:1
Page Range:pp. 15-34
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20060015UNSPECIFIED
ID Code:2461
Item Type:Article
Deposited On:06 Feb 2009 17:18
Last Modified:06 Feb 2009 16:18

Citation

Zhou, Ding; Lagoja, Irene M.; Van Aerschot, Arthur; Herdewijn, Piet (2006) Synthesis of Aminopropyl Phosphonate Nucleosides with Purine and Pyrimidine Bases. Collection of Czechoslovak Chemical Communications, 71 (1). pp. 15-34. ISSN 0010-0765

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