Tricyclic Purine Analogs Derived from 2-Amino-6-chloropurine and 2,6-Diaminopurine and Their Methylated Quaternary Salts

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Title:Tricyclic Purine Analogs Derived from 2-Amino-6-chloropurine and 2,6-Diaminopurine and Their Methylated Quaternary Salts
Creators:
Hořejší, Kateřina
Pohl, Radek
Holý, Antonín
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 71, 1, pp. 77-90
Uncontrolled Keywords:Fused heterocycles, Alkylation, Chloroacetaldehyde, Fluorescence, Purines, Nucleobases, Quaternization

Abstract

A novel series of tricyclic, etheno-bridged purine analogs was sythesized from 2-amino-6-(substituted amino)-9-methylpurines by cyclization with chloroacetaldehyde, with particular focus on the regioselectivity of the cyclization reaction and fluorescence properties. The analogs as well as the starting purines were alkylated with iodomethane, affording a new class of quaternary salts with potential biological activity. Neither significant fluorescence nor cytostatic effect was found. <p>

Title:Tricyclic Purine Analogs Derived from 2-Amino-6-chloropurine and 2,6-Diaminopurine and Their Methylated Quaternary Salts
Creators:
Hořejší, Kateřina
Pohl, Radek
Holý, Antonín
Uncontrolled Keywords:Fused heterocycles, Alkylation, Chloroacetaldehyde, Fluorescence, Purines, Nucleobases, Quaternization
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:71
Number:1
Page Range:pp. 77-90
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20060077UNSPECIFIED
ID Code:2465
Item Type:Article
Deposited On:06 Feb 2009 17:18
Last Modified:06 Feb 2009 16:19

Citation

Hořejší, Kateřina; Pohl, Radek; Holý, Antonín (2006) Tricyclic Purine Analogs Derived from 2-Amino-6-chloropurine and 2,6-Diaminopurine and Their Methylated Quaternary Salts. Collection of Czechoslovak Chemical Communications, 71 (1). pp. 77-90. ISSN 0010-0765

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