Synthesis of Oligoribonucleotides Containing Pyrimidine 2'-O-[(Hydroxyalkoxy)methyl]ribonucleosides

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Title:Synthesis of Oligoribonucleotides Containing Pyrimidine 2'-O-[(Hydroxyalkoxy)methyl]ribonucleosides
Creators:
Bobkov, Georgii V.
Brilliantov, Kirill V.
Mikhailov, Sergey N.
Rozenski, Jef
Van Aerschot, Arthur
Herdewijn, Piet
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 71, 6, pp. 804-819
Uncontrolled Keywords:2'-<i>O</i>-Modified nucleosides, Thermal denaturation, RNA duplexes, Ribonucleosides, Antisense agents, Oligonucleotides, siRNA

Abstract

A simple and efficient method for the preparation of pyrimidine 2'-<i>O</i>-[(2-hydroxyethoxy)methyl]ribonucleosides and 2'-<i>O</i>-[(3-hydroxypropoxy)methyl]ribonucleosides has been developed. These modified nucleosides were incorporated into oligoribonucleotides, which were shown to form stable RNA/RNA duplexes. <p>

Title:Synthesis of Oligoribonucleotides Containing Pyrimidine 2'-O-[(Hydroxyalkoxy)methyl]ribonucleosides
Creators:
Bobkov, Georgii V.
Brilliantov, Kirill V.
Mikhailov, Sergey N.
Rozenski, Jef
Van Aerschot, Arthur
Herdewijn, Piet
Uncontrolled Keywords:2'-<i>O</i>-Modified nucleosides, Thermal denaturation, RNA duplexes, Ribonucleosides, Antisense agents, Oligonucleotides, siRNA
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:71
Number:6
Page Range:pp. 804-819
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20060804UNSPECIFIED
ID Code:2508
Item Type:Article
Deposited On:06 Feb 2009 17:19
Last Modified:06 Feb 2009 16:19

Citation

Bobkov, Georgii V.; Brilliantov, Kirill V.; Mikhailov, Sergey N.; Rozenski, Jef; Van Aerschot, Arthur; Herdewijn, Piet (2006) Synthesis of Oligoribonucleotides Containing Pyrimidine 2'-O-[(Hydroxyalkoxy)methyl]ribonucleosides. Collection of Czechoslovak Chemical Communications, 71 (6). pp. 804-819. ISSN 0010-0765

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