Synthesis of 2'-C-Methylcytidine and 2'-C-Methyluridine Derivatives Modified in the 3'-Position as Potential Antiviral Agents

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Title:Synthesis of 2'-C-Methylcytidine and 2'-C-Methyluridine Derivatives Modified in the 3'-Position as Potential Antiviral Agents
Creators:
Pierra, Claire
Amador, Agnès
Badaroux, Eric
Storer, Richard
Gosselin, Gilles
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 71, 7, pp. 991-1010
Uncontrolled Keywords:2'-<i>C</i>-Methyl branched ribonucleosides, Fluorination, Pyrimidines, RNA viruses, Nucleosides, Hepatitis C virus, Deoxygenation, Antivirals

Abstract

As part of our anti-hepatitis C program, we recently discovered 2'-<i>C</i>-methylcytidine (<strong>1</strong>) and 2'-<i>C</i>-methyluridine (<strong>2</strong>), which are potent inhibitors in cell culture of several viruses (bovine viral diarrhea virus (BVDV), yellow fever virus (YFV)) closely related to HCV. In order to characterize structure-activity relationships, we introduced some structural and functional modifications into the 3'-position of 2'-<i>C</i>-methylcytidine and 2'-<i>C</i>-methyluridine. All these hitherto unknown compounds thus synthesized were tested for the activity against a wide range of viruses and found to be inactive. <p>

Title:Synthesis of 2'-C-Methylcytidine and 2'-C-Methyluridine Derivatives Modified in the 3'-Position as Potential Antiviral Agents
Creators:
Pierra, Claire
Amador, Agnès
Badaroux, Eric
Storer, Richard
Gosselin, Gilles
Uncontrolled Keywords:2'-<i>C</i>-Methyl branched ribonucleosides, Fluorination, Pyrimidines, RNA viruses, Nucleosides, Hepatitis C virus, Deoxygenation, Antivirals
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:71
Number:7
Page Range:pp. 991-1010
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20060991UNSPECIFIED
ID Code:2520
Item Type:Article
Deposited On:06 Feb 2009 17:19
Last Modified:06 Feb 2009 16:19

Citation

Pierra, Claire; Amador, Agnès; Badaroux, Eric; Storer, Richard; Gosselin, Gilles (2006) Synthesis of 2'-C-Methylcytidine and 2'-C-Methyluridine Derivatives Modified in the 3'-Position as Potential Antiviral Agents. Collection of Czechoslovak Chemical Communications, 71 (7). pp. 991-1010. ISSN 0010-0765

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