A Carbocyclic 7-Deazapurine-Pyrimidine Hybrid Nucleoside

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Title:A Carbocyclic 7-Deazapurine-Pyrimidine Hybrid Nucleoside
Creators:
Sunkara, Naresh K.
Mosley, Sylvester L.
Seley-Radtke, Katherine L.
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 71, 8, pp. 1161-1168
Uncontrolled Keywords:Isoadenosine, Pyrimidines, Carbanucleosides, Carbocyclic nucleosides, 7-Deazapurines, Nucleobases, Pyrrolopyrimidines

Abstract

The design, synthesis and rationale for the first example of a carbocyclic 7-deazapurine- pyrimidine hybrid nucleoside is described. The marriage of key structural features from the purine and pyrimidine nucleobase scaffolds has given rise to novel hybrid nucleobases designed to be recognized by biologically relevant purine- and pyrimidine-metabolizing enzymes. Pairing these hybrid bases with chemotherapeutically beneficial carbocyclic "sugars", in addition to utilizing the highly effective 7-deaza ring system, should result in chemotherapeutically useful nucleosides. The approach to realize the first 7-deazapurine-pyrimidine hybrid nucleoside <strong>3</strong> is presented herein. <p>

Title:A Carbocyclic 7-Deazapurine-Pyrimidine Hybrid Nucleoside
Creators:
Sunkara, Naresh K.
Mosley, Sylvester L.
Seley-Radtke, Katherine L.
Uncontrolled Keywords:Isoadenosine, Pyrimidines, Carbanucleosides, Carbocyclic nucleosides, 7-Deazapurines, Nucleobases, Pyrrolopyrimidines
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:71
Number:8
Page Range:pp. 1161-1168
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20061161UNSPECIFIED
ID Code:2531
Item Type:Article
Deposited On:06 Feb 2009 17:19
Last Modified:06 Feb 2009 16:19

Citation

Sunkara, Naresh K.; Mosley, Sylvester L.; Seley-Radtke, Katherine L. (2006) A Carbocyclic 7-Deazapurine-Pyrimidine Hybrid Nucleoside. Collection of Czechoslovak Chemical Communications, 71 (8). pp. 1161-1168. ISSN 0010-0765

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