Copper(II) Dihydroxybenzoates; Synthesis and Properties

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Title:Copper(II) Dihydroxybenzoates; Synthesis and Properties
Creators:
Sokolík, Jozef
Lučanská, Brigita
Plesch, Gustáv
Tumová, Ingrid
Valent, Aladár
Švec, Pavel
Krätsmár-Šmogrovič, Juraj
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 58, 6, pp. 1363-1370

Abstract

Compounds of composition Cu(2,5-DHB)<sub>2</sub> . 4 H<sub>2</sub>O (DHB, dihydroxybenoate anion) and Cu(2,Y-DHB)<sub>2</sub> . 8 H<sub>2</sub>O (Y = 4 or 6) were prepared as potential antiinflamatory gents with a view of pharmacological screening. The room-temperature magnetic moments allow to classify all compounds into the group of magnetically diluted copper(II) complexes. According the EPR and electronic spectra, the degree of tetragonal distortion increases passing from Cu(2,6-DHB)<sub>2</sub> . 8 H<sub>2</sub>O (<i>III</i>) through Cu(2,4-DHB)<sub>2</sub> . 8 H<sub>2</sub>O (<i>I</i>) to Cu(2,5-DHB)<sub>2</sub> . 4 H<sub>2</sub>O (<i>II</i>. The complexes differ also in the cooperative ordering in their structures. All tested compounds exhibit higher antiinflamatory activities (on dextran edema) than free carboxylic acids. However, their effects were accompanied with relatively high toxicity. Remarkable results were also achieved on evaluating the antipyretic activity.

Title:Copper(II) Dihydroxybenzoates; Synthesis and Properties
Creators:
Sokolík, Jozef
Lučanská, Brigita
Plesch, Gustáv
Tumová, Ingrid
Valent, Aladár
Švec, Pavel
Krätsmár-Šmogrovič, Juraj
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:58
Number:6
Page Range:pp. 1363-1370
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19931363UNSPECIFIED
ID Code:254
Item Type:Article
Deposited On:06 Feb 2009 16:59
Last Modified:06 Feb 2009 15:59

Citation

Sokolík, Jozef; Lučanská, Brigita; Plesch, Gustáv; Tumová, Ingrid; Valent, Aladár; Švec, Pavel; Krätsmár-Šmogrovič, Juraj (1993) Copper(II) Dihydroxybenzoates; Synthesis and Properties. Collection of Czechoslovak Chemical Communications, 58 (6). pp. 1363-1370. ISSN 0010-0765

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