Synthesis of 17α-Hydroxy Steroids: B-Norepitestosterone

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Title:Synthesis of 17α-Hydroxy Steroids: B-Norepitestosterone
Creators:
Kasal, Alexander
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 58, 9, pp. 2202-2210

Abstract

The key intermediate <i>VI</i> was prepared by two ways: by B ring contraction of an androst-5-ene-3β,17α-diol derivative <i>I</i> and by configurational inversion of the 17β-hydroxy group in a B-norandrost-5-ene-3β,17β-diol derivative <i>XII</i>. B-Norepitestosterone (<i>IX</i>) and its potentional metabolite <i>X</i> were then prepared by standard methodology. Both these compounds appear to be inhibitors of 5α-reductase.

Title:Synthesis of 17α-Hydroxy Steroids: B-Norepitestosterone
Creators:
Kasal, Alexander
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:58
Number:9
Page Range:pp. 2202-2210
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19932202UNSPECIFIED
ID Code:339
Item Type:Article
Deposited On:06 Feb 2009 17:00
Last Modified:06 Feb 2009 16:00

Citation

Kasal, Alexander (1993) Synthesis of 17α-Hydroxy Steroids: B-Norepitestosterone. Collection of Czechoslovak Chemical Communications, 58 (9). pp. 2202-2210. ISSN 0010-0765

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