The Mobility of Tryptophan and Dansyl Fluorophores in Labelled Poly(N-ethylacrylamide) and Poly(N-ethylmethacrylamide)

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Title:The Mobility of Tryptophan and Dansyl Fluorophores in Labelled Poly(N-ethylacrylamide) and Poly(N-ethylmethacrylamide)
Creators:
Mikeš, František
Výprachtický, Drahomír
Pecka, Jan
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 58, 10, pp. 2383-2395

Abstract

The mobility of tryptophan fluorophore in <i>N</i>-butyl-<i>N</i><sup>α</sup>-acetyltryptophanamide and in side chain of labelled poly(<i>N</i>-ethylacrylamide) and poly(<i>N</i>-ethylmethacrylamide) was investigated by the fluorescence depolarization method. The mobility of the fluorophore in the low-molecular-weight model is much higher than in side chains of the polymers. Different steric hindrance by the polymer backbone can explain the higher mobility of the fluorophore in poly(<i>N</i>-ethylacrylamide) and in poly(<i>N</i>-ethylmethacrylamide). The mobility of 5-dimethylamino-1-naphthalenesulfonamide (dansyl) fluorophore in side chains of labelled poly(<i>N</i>-ethylmethacrylamide) in the high-viscosity range increases with increasing number of methylene groups in side chains. The low-viscosity range, the rate s of conformational changes in short side chains (<i>n</i> = 2 - 7) are approximately constant and significantly decrease in long side chains (<i>n</i> = 10, 12). The drop in the rates is probably due to intramolecular association of the long hydrophobic chains in water.

Title:The Mobility of Tryptophan and Dansyl Fluorophores in Labelled Poly(N-ethylacrylamide) and Poly(N-ethylmethacrylamide)
Creators:
Mikeš, František
Výprachtický, Drahomír
Pecka, Jan
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:58
Number:10
Page Range:pp. 2383-2395
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19932383UNSPECIFIED
ID Code:355
Item Type:Article
Deposited On:06 Feb 2009 17:00
Last Modified:06 Feb 2009 16:00

Citation

Mikeš, František; Výprachtický, Drahomír; Pecka, Jan (1993) The Mobility of Tryptophan and Dansyl Fluorophores in Labelled Poly(N-ethylacrylamide) and Poly(N-ethylmethacrylamide). Collection of Czechoslovak Chemical Communications, 58 (10). pp. 2383-2395. ISSN 0010-0765

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