Resolution of a Racemic Corey Lactone via Enantioselective Esterification

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Title:Resolution of a Racemic Corey Lactone via Enantioselective Esterification
Creators:
Veselý, Ivan
Paleček, Jaroslav
Stibor, Ivan
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 57, 2, pp. 357-361

Abstract

The (-)-enantiomer of Corey lactone <i>Ia</i> has been separated from its (+)-enantiomer <i>Ib</i> via enantioselective esterification of the latter using glycerol tributyrate and catalytic amount of lipase from <i>Candida cylindracea</i> (EC 3.1.1.3) in an aprotic solvent at 20 to 40 °C during 5 to 48 h. The <i>Ic</i> obtained has been separated from <i>Ia</i> by column chromatography and converted back to <i>Ib</i> by acid catalyzed transesterification with methanol.

Title:Resolution of a Racemic Corey Lactone via Enantioselective Esterification
Creators:
Veselý, Ivan
Paleček, Jaroslav
Stibor, Ivan
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:57
Number:2
Page Range:pp. 357-361
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19920357UNSPECIFIED
ID Code:3760
Item Type:Article
Deposited On:06 Feb 2009 16:36
Last Modified:06 Feb 2009 15:38

Citation

Veselý, Ivan; Paleček, Jaroslav; Stibor, Ivan (1992) Resolution of a Racemic Corey Lactone via Enantioselective Esterification. Collection of Czechoslovak Chemical Communications, 57 (2). pp. 357-361. ISSN 0010-0765

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