Synthesis and Properties of "Hormonogene" and "Inhibitorogene" Type Oxytocin Analogs

[img]PDF - Authorized users only
Language: English
384Kb
Title:Synthesis and Properties of "Hormonogene" and "Inhibitorogene" Type Oxytocin Analogs
Creators:
Pal, B. C.
Slaninová, Jiřina
Barth, Tomislav
Trojnar, Jerzy
Lebl, Michal
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 57, 6, pp. 1345-1351

Abstract

N<sup>α</sup>-Glycyl, diglycyl and triglycyl [2-D and [2-L-<i>p</i>-ethylphenylalanine]oxytocin analogs were synthesized by the solid phase technology utilizing racemic <i>p</i>-ethylphenylalanine. Analogs containing this amino acid of D-configuration were shown to be weak uterotonic antagonists both in vitro and in vivo tests; the compound containing triglycyl residue in position 1 was shown to have prolonged time course of inhibitory action. Analogs containing the L-amino acid were shown to be inhibitors of uterotonic activity of oxytocin in vitro, but uterotonic agonists with prolonged effect in vivo.

Title:Synthesis and Properties of "Hormonogene" and "Inhibitorogene" Type Oxytocin Analogs
Creators:
Pal, B. C.
Slaninová, Jiřina
Barth, Tomislav
Trojnar, Jerzy
Lebl, Michal
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:57
Number:6
Page Range:pp. 1345-1351
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19921345UNSPECIFIED
ID Code:3796
Item Type:Article
Deposited On:06 Feb 2009 16:39
Last Modified:06 Feb 2009 15:40

Citation

Pal, B. C.; Slaninová, Jiřina; Barth, Tomislav; Trojnar, Jerzy; Lebl, Michal (1992) Synthesis and Properties of "Hormonogene" and "Inhibitorogene" Type Oxytocin Analogs. Collection of Czechoslovak Chemical Communications, 57 (6). pp. 1345-1351. ISSN 0010-0765

Repository Staff Only: item control page