Bromonitriles in Heterocyclic Synthesis. Synthesis and Reactions of Thiazolo[3,2-a]pyrimidines (III)

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Title:Bromonitriles in Heterocyclic Synthesis. Synthesis and Reactions of Thiazolo[3,2-a]pyrimidines (III)
Creators:
Geies, Ahmed A.
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 57, 7, pp. 1565-1569

Abstract

As a continuation of our previous work about the synthesis and properties of thiazolopyrimidines, which are expected to be of biological and medicinal importance, the present work is aimed to synthesize new polyfunctional substituted thiazolo[3,2-<i>a</i>]pyrimidines. Pyrimidine derivatives <i>I</i> were reacted with bromomalononitrile or ethyl bromocyanoacetate at room temperature in ethanol in presence of potassium hydroxide as a basic catalyst followed by refluxing the reaction mixture to give thiazolo[3,2-<i>a</i>]pyrimidines <i>IIa-IId</i>.

Title:Bromonitriles in Heterocyclic Synthesis. Synthesis and Reactions of Thiazolo[3,2-a]pyrimidines (III)
Creators:
Geies, Ahmed A.
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:57
Number:7
Page Range:pp. 1565-1569
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19921565UNSPECIFIED
ID Code:3820
Item Type:Article
Deposited On:06 Feb 2009 16:40
Last Modified:06 Feb 2009 15:41

Citation

Geies, Ahmed A. (1992) Bromonitriles in Heterocyclic Synthesis. Synthesis and Reactions of Thiazolo[3,2-a]pyrimidines (III). Collection of Czechoslovak Chemical Communications, 57 (7). pp. 1565-1569. ISSN 0010-0765

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