Biologically Important Physicochemical Properties of Some Cephalosporins

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Title:Biologically Important Physicochemical Properties of Some Cephalosporins
Creators:
Škvareninová, Katarína
Baláž, Štefan
Šturdík, Ernest
Veverka, Miroslav
Adamcová, Jana
Olexová, Jana
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 57, 8, pp. 1739-1746

Abstract

In the series of cephalosporin derivatives, consisting of eight 7-(R<sup>1</sup>-CH<sub>2</sub>-CO-NH)cephalosporanic acids and of seven analogical compounds with 3-acetoxymethyl replaced by 3-CH<sub>3</sub>, physicochemical properties, which are expected to play a role in their antibacterial effects (the transport rate parameters and partition coefficients in the systems 1-octanol-water and 1-octanol-buffer, dissociation constants of the 4-carboxyl group, reactivity towards L-glutathione imitating the nucleophilic groups of the cell components and hydrolysis rate parameters), were determined. Linear dependences were observed between the partition coefficients and the π-constants of the varying substituents as well as between reactivity towards SH-groups of L-glutathione and OH-groups. The relationship between the transport rate parameters and partition coefficients, both measured in buffered as well as non-buffered system, was described by a common non-linear equation.

Title:Biologically Important Physicochemical Properties of Some Cephalosporins
Creators:
Škvareninová, Katarína
Baláž, Štefan
Šturdík, Ernest
Veverka, Miroslav
Adamcová, Jana
Olexová, Jana
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:57
Number:8
Page Range:pp. 1739-1746
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19921739UNSPECIFIED
ID Code:3837
Item Type:Article
Deposited On:06 Feb 2009 16:41
Last Modified:06 Feb 2009 15:46

Citation

Škvareninová, Katarína; Baláž, Štefan; Šturdík, Ernest; Veverka, Miroslav; Adamcová, Jana; Olexová, Jana (1992) Biologically Important Physicochemical Properties of Some Cephalosporins. Collection of Czechoslovak Chemical Communications, 57 (8). pp. 1739-1746. ISSN 0010-0765

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