Cholecystokinin Heptapeptide Analogues with Multiple Modification in Peptide Chain

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Title:Cholecystokinin Heptapeptide Analogues with Multiple Modification in Peptide Chain
Creators:
Hlaváček, Jan
Pírková, Jana
Žertová, Miroslava
Pospíšek, Jan
Maletínská, Lenka
Slaninová, Jiřina
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 58, 11, pp. 2761-2765

Abstract

Using solid phase synthesis we prepared the cholecystokinin fragment Boc-CCK-7 (Boc-Tyr(SO<sub>3</sub><sup>-</sup>Na<sup>+</sup>)-Met-Gly-Trp-Met-Asp-Phe-NH<sub>2</sub>) <i>Ia</i> and its seven analogues <i>Ib - Ih</i>. In the analogues <i>Ib</i> and <i>Ic</i> the Met residue in the carboxyterminal part of the molecule was substituted for L- or D-Phe Me<sub>3</sub>. In the analogues <i>Id</i> and <i>Ie</i> with Phe residue substituted by L- or D-Phe Me<sub>3</sub> the Neo was inserted in the place of this Met residue and in the analogues <i>If</i> and <i>Ig</i>, an addition to PheMe<sub>3</sub> substitution in the carboxyterminus, both Met residues were replaced for Neo. This dual substitution for Met residues was also applied in the analogue <i>Ih</i> with coded Phe residue in the C-terminus.

Title:Cholecystokinin Heptapeptide Analogues with Multiple Modification in Peptide Chain
Creators:
Hlaváček, Jan
Pírková, Jana
Žertová, Miroslava
Pospíšek, Jan
Maletínská, Lenka
Slaninová, Jiřina
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:58
Number:11
Page Range:pp. 2761-2765
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19932761UNSPECIFIED
ID Code:393
Item Type:Article
Deposited On:06 Feb 2009 17:00
Last Modified:06 Feb 2009 16:00

Citation

Hlaváček, Jan; Pírková, Jana; Žertová, Miroslava; Pospíšek, Jan; Maletínská, Lenka; Slaninová, Jiřina (1993) Cholecystokinin Heptapeptide Analogues with Multiple Modification in Peptide Chain. Collection of Czechoslovak Chemical Communications, 58 (11). pp. 2761-2765. ISSN 0010-0765

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