Synthesis and Some Pharmacological Properties of Six New Analogs of Arginine-Vasopressin Substituted in Position 2 with β-Thienylalanine or Prolonged on the N-Terminus with 1-Adamantaneacetic Acid

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Title:Synthesis and Some Pharmacological Properties of Six New Analogs of Arginine-Vasopressin Substituted in Position 2 with β-Thienylalanine or Prolonged on the N-Terminus with 1-Adamantaneacetic Acid
Creators:
Konieczna, Ewa
Czaja, Malgorzata
Lammek, Bernard
Slaninová, Jiřina
Barth, Tomislav
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 58, 12, pp. 2994-2999

Abstract

Six new analogs of arginine-vasopressin, four of them substituted in position 2 with β-thienylalanine and two prolonged on the n-terminus by acylation with 1-adamantaneacetic acid, were synthesized on chloromethylated resin using Boc strategy and DCC or DCC-HOBt to form peptide bond. The activity of the analogs was fairly low, however, one of the peptides, namely [Cpp<sup>1</sup>, Thi<sup>2</sup>, Val<sup>4</sup>]AVP, showed selectivity in antiuterotonic, antipressor and anti-antidiuretic effects.

Title:Synthesis and Some Pharmacological Properties of Six New Analogs of Arginine-Vasopressin Substituted in Position 2 with β-Thienylalanine or Prolonged on the N-Terminus with 1-Adamantaneacetic Acid
Creators:
Konieczna, Ewa
Czaja, Malgorzata
Lammek, Bernard
Slaninová, Jiřina
Barth, Tomislav
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:58
Number:12
Page Range:pp. 2994-2999
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19932994UNSPECIFIED
ID Code:414
Item Type:Article
Deposited On:06 Feb 2009 17:00
Last Modified:06 Feb 2009 16:00

Citation

Konieczna, Ewa; Czaja, Malgorzata; Lammek, Bernard; Slaninová, Jiřina; Barth, Tomislav (1993) Synthesis and Some Pharmacological Properties of Six New Analogs of Arginine-Vasopressin Substituted in Position 2 with β-Thienylalanine or Prolonged on the N-Terminus with 1-Adamantaneacetic Acid. Collection of Czechoslovak Chemical Communications, 58 (12). pp. 2994-2999. ISSN 0010-0765

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