Spirocyclic Dipeptides of 1-Amino-1-cyclohexanecarboxylic Acid

[img]PDF - Authorized users only
Language: English
86Kb
Title:Spirocyclic Dipeptides of 1-Amino-1-cyclohexanecarboxylic Acid
Creators:
Vinšová, Jarmila
Kosař, Karel
Kasafírek, Evžen
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 59, 1, pp. 195-202

Abstract

<p>Spirocyclic cyclodipeptides with 1-amino-1-cyclohexanecarboxylic acid of the general formula cyclo(-Ach-A-), where A is Gly, L-Ala, D-Ala, L-Val, D-Val, L-Leu, D-Leu, D-Pgl, L-Phe or D-Phe, have been prepared by cyclization of the corresponding linear dipeptide methyl esters. The peptides cyclo(-L- or D-Ala-Ach-), cyclo(-L-Val-Ach-) and cyclo(-D-Leu-Ach-) show higher activity in the Chick Embryotoxicity Screening Test when compared with derivatives containing 1-amino-1-cyclopentanecarboxylic acid or 1-amino-1-cyclobutanecarboxylic acid.

Title:Spirocyclic Dipeptides of 1-Amino-1-cyclohexanecarboxylic Acid
Creators:
Vinšová, Jarmila
Kosař, Karel
Kasafírek, Evžen
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:59
Number:1
Page Range:pp. 195-202
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19940195UNSPECIFIED
ID Code:431
Item Type:Article
Deposited On:06 Feb 2009 17:00
Last Modified:06 Feb 2009 16:01

Citation

Vinšová, Jarmila; Kosař, Karel; Kasafírek, Evžen (1994) Spirocyclic Dipeptides of 1-Amino-1-cyclohexanecarboxylic Acid. Collection of Czechoslovak Chemical Communications, 59 (1). pp. 195-202. ISSN 0010-0765

Repository Staff Only: item control page