Total synthesis of the potent antifungal agents bengazole C and E

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Title:Total synthesis of the potent antifungal agents bengazole C and E
Creators:
Enríquez-García, Álvaro
Ley, Steven V.
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 74, 6, pp. 887-900
Uncontrolled Keywords:Total synthesis, Oxazoles, Antifungal agents, Natural products, Marine compounds, Bengazoles, Cycloaddition

Abstract

The bengazoles are marine natural products with unique structure, containing two oxazole rings flanking a single carbon. They show very potent antifungal activity. The total syntheses of bengazole C and E are described following a convergent route which involves diastereoselective cycloaddition of an appropriately substituted nitrile oxide with a butane-1,2-diacetal-protected alkenediol as the key step.

Title:Total synthesis of the potent antifungal agents bengazole C and E
Creators:
Enríquez-García, Álvaro
Ley, Steven V.
Uncontrolled Keywords:Total synthesis, Oxazoles, Antifungal agents, Natural products, Marine compounds, Bengazoles, Cycloaddition
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:74
Number:6
Page Range:pp. 887-900
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc2009016UNSPECIFIED
ID Code:4428
Item Type:Article
Deposited On:30 Jun 2009 16:11
Last Modified:30 Jun 2009 14:11

Citation

Enríquez-García, Álvaro; Ley, Steven V. (2009) Total synthesis of the potent antifungal agents bengazole C and E. Collection of Czechoslovak Chemical Communications, 74 (6). pp. 887-900. ISSN 0010-0765

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