Synthesis of Some Epitestosterone Analogues

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Title:Synthesis of Some Epitestosterone Analogues
Creators:
Chodounská, Hana
Slavíková, Barbora
Kasal, Alexander
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 59, 2, pp. 435-443

Abstract

<p>11β-Hydroxyandrost-4-ene-3,17-dione (<i>III</i>) was converted into a potential metabolite of epitestosterone - 11β,17α-dihydroxyandrost-4-en-3-one (<i>II</i>) in 5 steps, including the inversion of configuration of a 17β-hydroxy group. This inversion was not feasible in the preparation of the analogues <i>X</i>, <i>XIV</i>, <i>XX</i>, and <i>XXII</i>, where the 17α-hydroxy group was introduced first and only then was the rest of the molecule modified.

Title:Synthesis of Some Epitestosterone Analogues
Creators:
Chodounská, Hana
Slavíková, Barbora
Kasal, Alexander
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:59
Number:2
Page Range:pp. 435-443
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19940435UNSPECIFIED
ID Code:460
Item Type:Article
Deposited On:06 Feb 2009 17:01
Last Modified:06 Feb 2009 16:01

Citation

Chodounská, Hana; Slavíková, Barbora; Kasal, Alexander (1994) Synthesis of Some Epitestosterone Analogues. Collection of Czechoslovak Chemical Communications, 59 (2). pp. 435-443. ISSN 0010-0765

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