Voltammetric and amperometric determination of N-nitroso antineoplastic drugs at mercury and amalgam electrodes

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Title:Voltammetric and amperometric determination of N-nitroso antineoplastic drugs at mercury and amalgam electrodes
Creators:
Pecková, Karolina
Vrzalová, Lucie
Bencko, Vladimír
Barek, Jiří
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 74, 11-12, pp. 1697-1713
Uncontrolled Keywords:Streptozotocin, Nitroso compounds, Carmustine, Hanging mercury drop electrode, Amperometry, Voltammetry, Electrochemistry, Silver solid amalgam electrode, Lomustine

Abstract

A hanging mercury drop electrode and a mercury meniscus modified silver solid amalgam electrode were used as electroanalytical sensors for voltammetric determination of antineoplastic drugs carmustine, lomustine and streptozotocin containing reducible N-nitroso groups. On the example of carmustine it was shown that its one-step reduction proceeds at substantially more negative potentials at amalgam electrode as compared with mercury electrode. Both electrodes offer satisfactory repeatability of current response (relative standard deviations < 5%) using DC voltammetry and differential pulse voltammetry. The achieved limits of determination lie mostly in the 10<sup>–7</sup> mol l<sup>–1</sup> concentration range. The mentioned voltammetric methods were applied to determination of carmustine and lomustine in pharmaceutical formulations. Further, the mercury meniscus modified silver solid amalgam electrode was employed in a “wall-jet” amperometric detection cell in the determination of carmustine by flow injection analysis. Under optimized conditions (run electrolyte Britton– Robinson buffer of pH 7.0; flow rate 5.5 ml min<sup>–1</sup>; detection potential –1.5 V; injection volume 0.02 ml) the limit of quantitation 7.1 × 10<sup>–6</sup> mol l<sup>–1</sup> was achieved.

Title:Voltammetric and amperometric determination of N-nitroso antineoplastic drugs at mercury and amalgam electrodes
Creators:
Pecková, Karolina
Vrzalová, Lucie
Bencko, Vladimír
Barek, Jiří
Uncontrolled Keywords:Streptozotocin, Nitroso compounds, Carmustine, Hanging mercury drop electrode, Amperometry, Voltammetry, Electrochemistry, Silver solid amalgam electrode, Lomustine
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:74
Number:11-12
Page Range:pp. 1697-1713
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc2009112UNSPECIFIED
ID Code:4857
Item Type:Article
Deposited On:17 Feb 2010 16:45
Last Modified:17 Feb 2010 15:45

Citation

Pecková, Karolina; Vrzalová, Lucie; Bencko, Vladimír; Barek, Jiří (2009) Voltammetric and amperometric determination of N-nitroso antineoplastic drugs at mercury and amalgam electrodes. Collection of Czechoslovak Chemical Communications, 74 (11-12). pp. 1697-1713. ISSN 0010-0765

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