Weak Oxytocin Antagonists from Minor Modification of the Cyclic Portion of Agonists

[img]PDF - Authorized users only
Language: English
23Kb
Title:Weak Oxytocin Antagonists from Minor Modification of the Cyclic Portion of Agonists
Creators:
Assimomytis, N.
Manessi-Zoupa, E.
Cordopatis, P.
Theodoropoulos, D.
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 59, 3, pp. 718-720

Abstract

<p>[(OMe)Ser<sup>5</sup>]-oxytocin (<i>I</i>), [(OMe)Thr<sup>5</sup>]-oxytocin (<i>II</i>) and [Aib<sup>3</sup>]-oxytocin (<i>III</i>) were synthesized by solid phase techniques. The three analogs were found to be relatively weak antagonists with p<i>A</i><sub>2</sub> values 5.7 (for <i>I</i>), 5.8 (for <i>II</i>) and 5.8 (for <i>III</i>), respectively, in the rat uterotonic <i>in vitro</i> assay. They were all inactive in the pressor and galactogonic assays.

Title:Weak Oxytocin Antagonists from Minor Modification of the Cyclic Portion of Agonists
Creators:
Assimomytis, N.
Manessi-Zoupa, E.
Cordopatis, P.
Theodoropoulos, D.
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:59
Number:3
Page Range:pp. 718-720
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19940718UNSPECIFIED
ID Code:494
Item Type:Article
Deposited On:06 Feb 2009 17:01
Last Modified:06 Feb 2009 16:01

Citation

Assimomytis, N.; Manessi-Zoupa, E.; Cordopatis, P.; Theodoropoulos, D. (1994) Weak Oxytocin Antagonists from Minor Modification of the Cyclic Portion of Agonists. Collection of Czechoslovak Chemical Communications, 59 (3). pp. 718-720. ISSN 0010-0765

Repository Staff Only: item control page