Synthesis and biological activity of four vasopressin analogues substituted in position 2 by p-fluorophenylalanine

[img]PDF - Authorized users only
Language: English
212Kb
Title:Synthesis and biological activity of four vasopressin analogues substituted in position 2 by p-fluorophenylalanine
Creators:
Lammek, Bernard
Derdowska, Izabela
Kupryszewski, Gotfryd
Slaninová, Jiřina
Barth, Tomislav
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 56, 4, pp. 933-938

Abstract

Tyrosine in position 2 of AVP, dAVP, [Cpp<sup>1</sup>]AVP and [Cpp<sup>1</sup>, Val<sup>4</sup>]AVP was substituted by <i>p</i>-fluorophenylalanine and an effect of this change on agonistic/antagonistic activity in uterotonic, pressor or anti-antidiuretic test was followed. All the prepared analogues were found inhibitory in uterotonic test, however the inhibitory potency was rather low. As far as the pressor activity is concerned, the agonistic potency was slightly decreased (2-4 times), in comparison with the strong decrease of the inhibitory potency.

Title:Synthesis and biological activity of four vasopressin analogues substituted in position 2 by p-fluorophenylalanine
Creators:
Lammek, Bernard
Derdowska, Izabela
Kupryszewski, Gotfryd
Slaninová, Jiřina
Barth, Tomislav
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:56
Number:4
Page Range:pp. 933-938
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19910933UNSPECIFIED
ID Code:5010
Item Type:Article
Deposited On:22 Feb 2010 11:28
Last Modified:22 Feb 2010 10:28

Citation

Lammek, Bernard; Derdowska, Izabela; Kupryszewski, Gotfryd; Slaninová, Jiřina; Barth, Tomislav (1991) Synthesis and biological activity of four vasopressin analogues substituted in position 2 by p-fluorophenylalanine. Collection of Czechoslovak Chemical Communications, 56 (4). pp. 933-938. ISSN 0010-0765

Repository Staff Only: item control page