Comparison of binding affinities of a series of oxytocin analogues to uterine and mammary gland receptors and their biological potencies

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Title:Comparison of binding affinities of a series of oxytocin analogues to uterine and mammary gland receptors and their biological potencies
Creators:
Slaninová, Jiřina
Hackenberg, Mario
Fahrenholz, Falk
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 56, 4, pp. 939-943

Abstract

The affinity of 12 oxytocin analogues of similar structure but differences in conformational freedom and agonistic and antagonistic properties to receptors in guinea pig uterus and rat mammary gland membrane preparations was determined by competitive binding experiments using tritiated oxytocin. The values obtained for the apparent dissociation constant <i>K</i><sub>D</sub> were compared to the values of biological activities from classical pharmacological tests ( uterotonic test in vitro and galactogogic test in vivo).

Title:Comparison of binding affinities of a series of oxytocin analogues to uterine and mammary gland receptors and their biological potencies
Creators:
Slaninová, Jiřina
Hackenberg, Mario
Fahrenholz, Falk
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:56
Number:4
Page Range:pp. 939-943
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19910939UNSPECIFIED
ID Code:5011
Item Type:Article
Deposited On:22 Feb 2010 11:28
Last Modified:22 Feb 2010 10:28

Citation

Slaninová, Jiřina; Hackenberg, Mario; Fahrenholz, Falk (1991) Comparison of binding affinities of a series of oxytocin analogues to uterine and mammary gland receptors and their biological potencies. Collection of Czechoslovak Chemical Communications, 56 (4). pp. 939-943. ISSN 0010-0765

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