The chemotherapy of psoriasis with azaribine: Mirage or miracle

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Title:The chemotherapy of psoriasis with azaribine: Mirage or miracle
Creators:
Drell, William
Škoda, Jan
Welch, Arnold D.
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 56, 5, pp. 945-953

Abstract

An antimetabolite, administered orally, which alleviates the symptoms and signs of severe psoriasis, azaribine (triacetyl-6-azauridine), was approved by the Food and Drug Administration (FDA of the USA) for clinical use in 1975, but 18 months later approval was withdrawn. The mechanism of action of azaribine (as a precursor of 6-azauridine 5’-azauridine 5’-monophosphate) is described and the probable cause of the infrequent vascular thromboses and a means of preventing them (by the co-administration of pyridoxine) are discussed.

Title:The chemotherapy of psoriasis with azaribine: Mirage or miracle
Creators:
Drell, William
Škoda, Jan
Welch, Arnold D.
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:56
Number:5
Page Range:pp. 945-953
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19910945UNSPECIFIED
ID Code:5012
Item Type:Article
Deposited On:22 Feb 2010 11:28
Last Modified:22 Feb 2010 10:28

Citation

Drell, William; Škoda, Jan; Welch, Arnold D. (1991) The chemotherapy of psoriasis with azaribine: Mirage or miracle. Collection of Czechoslovak Chemical Communications, 56 (5). pp. 945-953. ISSN 0010-0765

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