Enantioselective addition of optically active organotitanium reagents to benzaldehyde

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Title:Enantioselective addition of optically active organotitanium reagents to benzaldehyde
Creators:
Červinka, Otakar
Pátek, Marcel
Stružka, Vladimír
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 56, 5, pp. 1032-1036

Abstract

Addition of optically active alkyltitanium (IV) reagents <i>IIb</i> and <i>IIc</i> to benzaldehyde afforded optically active 1-phenylethanol (<i>V</i>) of 37-48% optical purity and 1-phenylpentanol (<i>VI</i>) of 10-24% optical purity. Reagents <i>IIb</i> and <i>IIc</i> were prepared with the use of (1<i>R</i>,2<i>S</i>)-(-)-1-phenyl-1,2-propanediol (<i>III</i>) and (1<i>R</i>,2<i>S</i>)-(+)-1-cyclohexyl-1,2-propanediol (<i>IV</i>) as optically active components. Relations between the enantioselectivity achieved and reaction conditions are discussed.

Title:Enantioselective addition of optically active organotitanium reagents to benzaldehyde
Creators:
Červinka, Otakar
Pátek, Marcel
Stružka, Vladimír
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:56
Number:5
Page Range:pp. 1032-1036
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19911032UNSPECIFIED
ID Code:5020
Item Type:Article
Deposited On:22 Feb 2010 11:28
Last Modified:22 Feb 2010 10:29

Citation

Červinka, Otakar; Pátek, Marcel; Stružka, Vladimír (1991) Enantioselective addition of optically active organotitanium reagents to benzaldehyde. Collection of Czechoslovak Chemical Communications, 56 (5). pp. 1032-1036. ISSN 0010-0765

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