Synthesis of N-[(3-substituted phenoxy)alkyl]acetohydroxamic acids, potential inhibitors of the enzyme 5-lipoxygenase

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Title:Synthesis of N-[(3-substituted phenoxy)alkyl]acetohydroxamic acids, potential inhibitors of the enzyme 5-lipoxygenase
Creators:
Svoboda, Jiří
Paleček, Jaroslav
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 56, 6, pp. 1317-1332

Abstract

The synthesis of the title compounds starts from methyl (3-subst. phenoxy)alkanoates <i>II</i> which are reduced to the corresponding aldehydes and then transformed to oximes <i>V</i> by reaction with hydroxylamine. Reduction with borane-pyridine complex gives the hydroxylamines <i>VI</i> which on diacetylation and partial deacetylation provide the hydroxamic acids <i>VIII</i>.

Title:Synthesis of N-[(3-substituted phenoxy)alkyl]acetohydroxamic acids, potential inhibitors of the enzyme 5-lipoxygenase
Creators:
Svoboda, Jiří
Paleček, Jaroslav
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:56
Number:6
Page Range:pp. 1317-1332
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19911317UNSPECIFIED
ID Code:5054
Item Type:Article
Deposited On:22 Feb 2010 11:29
Last Modified:22 Feb 2010 10:29

Citation

Svoboda, Jiří; Paleček, Jaroslav (1991) Synthesis of N-[(3-substituted phenoxy)alkyl]acetohydroxamic acids, potential inhibitors of the enzyme 5-lipoxygenase. Collection of Czechoslovak Chemical Communications, 56 (6). pp. 1317-1332. ISSN 0010-0765

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