6-(6-Substituted amino-2-hydroxypropyl)-5,6,7,8-tetrahydrodibenz[c, e]azocines

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Title:6-(6-Substituted amino-2-hydroxypropyl)-5,6,7,8-tetrahydrodibenz[c, e]azocines
Creators:
Szemes, Fridrich
Rybár, Alfonz
Hrnčiar, Pavol
Solčániová, Eva
Gattnár, Ondrej
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 56, 8, pp. 1725-1731

Abstract

Nucleophilic addition of alkyl-, cycloalkylamines, or saturated nitrogen-containing heterocycles to isolated or in situ generated 6-(2,3-epoxypropyl)-5,6,7,8-tetrahydrodibenz[<i>c,e</i>]azocine (<i>III</i>) afforded 6-(3-substituted amino-2-hydroxypropyl)-5,6,7,8-tetrahydrodibenz[<i>c,e</i>]azocines <i>IV</i> and their hydrochlorides. The starting 5,6,7,8-tetrahydrodibenz[<i>c,e</i>]azocine (<i>I</i>) reacted with 1-chloro-2,3-epoxypropane to yield 6-(3-chloro-2-hydroxypropyl)-5,6,7,8-tetrahydrodibenz[<i>c,e</i>]azocine (<i>II</i>), which, on treatment with sodium ethoxide or an excess of an amine eliminated hydrogen chloride to give the intermediate <i>III</i>.

Title:6-(6-Substituted amino-2-hydroxypropyl)-5,6,7,8-tetrahydrodibenz[c, e]azocines
Creators:
Szemes, Fridrich
Rybár, Alfonz
Hrnčiar, Pavol
Solčániová, Eva
Gattnár, Ondrej
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:56
Number:8
Page Range:pp. 1725-1731
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19911725UNSPECIFIED
ID Code:5099
Item Type:Article
Deposited On:22 Feb 2010 11:30
Last Modified:22 Feb 2010 10:30

Citation

Szemes, Fridrich; Rybár, Alfonz; Hrnčiar, Pavol; Solčániová, Eva; Gattnár, Ondrej (1991) 6-(6-Substituted amino-2-hydroxypropyl)-5,6,7,8-tetrahydrodibenz[c, e]azocines. Collection of Czechoslovak Chemical Communications, 56 (8). pp. 1725-1731. ISSN 0010-0765

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