Synthesis and biological activity in GPI test of scyliorhinin I and its analogues modified in position 8 by Leu, Sar and Pro residues

[img]PDF - Authorized users only
Language: English
238Kb
Title:Synthesis and biological activity in GPI test of scyliorhinin I and its analogues modified in position 8 by Leu, Sar and Pro residues
Creators:
Rolka, Krzysztof
Kupryszewski, Gotfryd
Janas, Piotr
Myszor, Jarosław
Herman, Zbigniew S.
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 56, 9, pp. 1957-1962

Abstract

Three analogues of scyliorhinin I with Gly in position 8 substituted with Leu, Sar and Pro residues, were synthesized by the solid-phase method. The agonistic activity was determined on isolated guinea pig ileum. Analogues with Sar and Pro in position 8 appeared to be significantly more active than scyliorhinin I and the analogues with Leu in this position. For all analogues the Hill cooperativity coefficient is much lower than one suggesting that the interaction of these peptides with tachykinin receptor(s) in not a one-step reaction.

Title:Synthesis and biological activity in GPI test of scyliorhinin I and its analogues modified in position 8 by Leu, Sar and Pro residues
Creators:
Rolka, Krzysztof
Kupryszewski, Gotfryd
Janas, Piotr
Myszor, Jarosław
Herman, Zbigniew S.
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:56
Number:9
Page Range:pp. 1957-1962
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19911957UNSPECIFIED
ID Code:5123
Item Type:Article
Deposited On:22 Feb 2010 11:30
Last Modified:22 Feb 2010 10:31

Citation

Rolka, Krzysztof; Kupryszewski, Gotfryd; Janas, Piotr; Myszor, Jarosław; Herman, Zbigniew S. (1991) Synthesis and biological activity in GPI test of scyliorhinin I and its analogues modified in position 8 by Leu, Sar and Pro residues. Collection of Czechoslovak Chemical Communications, 56 (9). pp. 1957-1962. ISSN 0010-0765

Repository Staff Only: item control page