Synthesis and analgetic efficiency of some oxy and oxo derivatives of 4(3H)-quinazolinone

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Title:Synthesis and analgetic efficiency of some oxy and oxo derivatives of 4(3H)-quinazolinone
Creators:
Fišnerová, Ludmila
Brunová, Bohumila
Kocfeldová, Zuzana
Tíkalová, Jana
Maturová, Eva
Grimová, Jaroslava
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 56, 11, pp. 2373-2381

Abstract

A series of 3-substituted 4(3<i>H</i>)-quinazolinone derivatives have been prepared by alkylation of 4(3<i>H</i>)-quinazolinone with halogenoethers, halogenoketones, and Mannich bases, and the products have been tested for analgetic effects.The most interesting representatives of the oxy and oxo derivatives are 3-[2-(2’,4’-difluoro-4-biphenylyloxy)ethyl]-4(3<i>H</i>)-quinazolinone (<i>Ib</i>) and 3-[2-oxo-2-(4-biphenylyl)ethyl]-4(3<i>H</i>)-quinazolinone (<i>IIi</i>), respectively. Among the group of oxy derivatives also the 2-methylderivative <i>Ig</i> has been prepared, viz. by alkylation of 2’,4’-difluoro-4-hydroxybiphenyl with 2-methyl-3-(2-chloroethyl)-4(3<i>H</i>)-quinazolinone; the activity of <i>Ig</i> is lower than that of <i>Ib</i>.

Title:Synthesis and analgetic efficiency of some oxy and oxo derivatives of 4(3H)-quinazolinone
Creators:
Fišnerová, Ludmila
Brunová, Bohumila
Kocfeldová, Zuzana
Tíkalová, Jana
Maturová, Eva
Grimová, Jaroslava
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:56
Number:11
Page Range:pp. 2373-2381
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19912373UNSPECIFIED
ID Code:5166
Item Type:Article
Deposited On:22 Feb 2010 11:32
Last Modified:22 Feb 2010 10:32

Citation

Fišnerová, Ludmila; Brunová, Bohumila; Kocfeldová, Zuzana; Tíkalová, Jana; Maturová, Eva; Grimová, Jaroslava (1991) Synthesis and analgetic efficiency of some oxy and oxo derivatives of 4(3H)-quinazolinone. Collection of Czechoslovak Chemical Communications, 56 (11). pp. 2373-2381. ISSN 0010-0765

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