Reaction of 4-aroyl-2(3H)-dihydrofuranones with hydroxylamine hydrochloride. Synthesis and pharmacological study of a series of 3-aryl-4,5-dihydro-4-isoxazoleacetic acids

[img]PDF - Authorized users only
Language: English
167Kb
Title:Reaction of 4-aroyl-2(3H)-dihydrofuranones with hydroxylamine hydrochloride. Synthesis and pharmacological study of a series of 3-aryl-4,5-dihydro-4-isoxazoleacetic acids
Creators:
Curzu, Maria M.
Pinna, Gérard A.
Cignarella, Giorgio
Barlocco, Daniela
Demontis, Maria Piera
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 56, 11, pp. 2494-2499

Abstract

We have synthesized and tested for their antiinflammatory activity a new series of 3-aryl-4,5-dihydro-4-isoxazoleacetic acids (<i>IVa-IVg</i>). Preliminary pharmacological results seem to indicate the 3-phenyl derivative <i>IVa</i> as the most interesting compound. In fact, when tested against carrageenin edema in Wistar rats, it shows antiinflammatory activity comparable to that of naproxene, taken as reference drug, though of shorter duration. All the substituted phenyl derivatives were less active (<i>IVd-IVf</i>) or inactive (<i>IVb, IVc, IVg</i>).

Title:Reaction of 4-aroyl-2(3H)-dihydrofuranones with hydroxylamine hydrochloride. Synthesis and pharmacological study of a series of 3-aryl-4,5-dihydro-4-isoxazoleacetic acids
Creators:
Curzu, Maria M.
Pinna, Gérard A.
Cignarella, Giorgio
Barlocco, Daniela
Demontis, Maria Piera
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:56
Number:11
Page Range:pp. 2494-2499
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19912494UNSPECIFIED
ID Code:5180
Item Type:Article
Deposited On:22 Feb 2010 11:32
Last Modified:22 Feb 2010 10:32

Citation

Curzu, Maria M.; Pinna, Gérard A.; Cignarella, Giorgio; Barlocco, Daniela; Demontis, Maria Piera (1991) Reaction of 4-aroyl-2(3H)-dihydrofuranones with hydroxylamine hydrochloride. Synthesis and pharmacological study of a series of 3-aryl-4,5-dihydro-4-isoxazoleacetic acids. Collection of Czechoslovak Chemical Communications, 56 (11). pp. 2494-2499. ISSN 0010-0765

Repository Staff Only: item control page