Theoretical interpretation of retention data of polychlorinated biphenyls in liquid chromatography

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Title:Theoretical interpretation of retention data of polychlorinated biphenyls in liquid chromatography
Creators:
Jakuš, Vladimír
Miertuš, Stanislav
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 56, 12, pp. 2833-2848

Abstract

The new approach to the theoretical evaluation of Gibbs free energy of solvation is applied to the estimation of retention data in RP-HPLC. Simple models of stationary and mobile phases in RP-HPLC are used. The correlation between retention data of a series of 15 polychlorinated biphenyls (measured on chemically bonded stationary phase with C<sub>18</sub> alkyl chains) and the contribution of the Gibbs solvation energy is investigated in order to determine the dominant factor controlling retention. The retention in RP-HPLC can be predicted on the basis of our thermodynamic retention model. This approach is suitable especially when no standards are available for some derivatives (e.g. metabolites of biologically active substances) and when the interpretation of experimental elution is not clear.

Title:Theoretical interpretation of retention data of polychlorinated biphenyls in liquid chromatography
Creators:
Jakuš, Vladimír
Miertuš, Stanislav
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:56
Number:12
Page Range:pp. 2833-2848
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19912833UNSPECIFIED
ID Code:5189
Item Type:Article
Deposited On:22 Feb 2010 11:32
Last Modified:22 Feb 2010 10:32

Citation

Jakuš, Vladimír; Miertuš, Stanislav (1991) Theoretical interpretation of retention data of polychlorinated biphenyls in liquid chromatography. Collection of Czechoslovak Chemical Communications, 56 (12). pp. 2833-2848. ISSN 0010-0765

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