Correlation of structural parameters with antituberculotic activity in a group of 2-benzamidobenzothiazoles

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Title:Correlation of structural parameters with antituberculotic activity in a group of 2-benzamidobenzothiazoles
Creators:
Waisser, Karel
Kuneš, Jiří
Odlerová, Želmíra
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 56, 12, pp. 2978-2985

Abstract

Fourteen 2-benzamidobenzothiazole derivatives substituted in the benzoyl group and 2-cinnamamidobenzothiazole have been synthesized. The prediction of active structures by the method by Topliss gives incorrect results but, as shown on the basis of the Hansch QSAR analysis, the 2-(4-dimethylaminobenzamido)benzothiazole synthesized on the basis of the QSAR procedure by Topliss behaves anomalously also in the procedure by Hansch. Regression equations of the Hansch type have been found in which the antituberculotic activity is interpreted by lipophilicity and electronic effects of substituents. When tested in vitro, the most active compounds are comparable with ethionamide.

Title:Correlation of structural parameters with antituberculotic activity in a group of 2-benzamidobenzothiazoles
Creators:
Waisser, Karel
Kuneš, Jiří
Odlerová, Želmíra
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:56
Number:12
Page Range:pp. 2978-2985
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19912978UNSPECIFIED
ID Code:5203
Item Type:Article
Deposited On:22 Feb 2010 11:32
Last Modified:22 Feb 2010 10:33

Citation

Waisser, Karel; Kuneš, Jiří; Odlerová, Želmíra (1991) Correlation of structural parameters with antituberculotic activity in a group of 2-benzamidobenzothiazoles. Collection of Czechoslovak Chemical Communications, 56 (12). pp. 2978-2985. ISSN 0010-0765

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