Cyclohexylideneacetyl Isothiocyanate. Precursor for the Synthesis of 1,3-Thiazaspirocycloalkanes and 1,3-Diazaspirocycloalkanes

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Title:Cyclohexylideneacetyl Isothiocyanate. Precursor for the Synthesis of 1,3-Thiazaspirocycloalkanes and 1,3-Diazaspirocycloalkanes
Creators:
Török, Marcel
Dzurilla, Milan
Kutschy, Peter
Imrich, Ján
Danihel, Ivan
Rademacher, Paul
Bandmann, Heinz
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 59, 5, pp. 1203-1210

Abstract

<p>The <i>N</i>-(4-substituted phenyl)-<i>N'</i>-cyclohexylideneacetylthioureas <i>IIa</i> - <i>IIf</i> were readily prepared by the reaction of cyclohexylideneacetyl isothiocyanate <i>I</i> with 4-substituted anilines. They were cyclized to the 2-(4-substituted phenylimino)-4-oxo-1,3-thiazaspiro[5.5]undecanes <i>IIIa</i> - <i>IIIe</i> in the presence of boron trifluoride etherate and to the 1-(4-substituted phenyl)-4-oxo-2-thioxo-1,3-diazaspiro[5.5]undecanes <i>IVa</i>, <i>IVc</i> - <i>IVf</i> in alkaline medium.

Title:Cyclohexylideneacetyl Isothiocyanate. Precursor for the Synthesis of 1,3-Thiazaspirocycloalkanes and 1,3-Diazaspirocycloalkanes
Creators:
Török, Marcel
Dzurilla, Milan
Kutschy, Peter
Imrich, Ján
Danihel, Ivan
Rademacher, Paul
Bandmann, Heinz
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:59
Number:5
Page Range:pp. 1203-1210
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19941203UNSPECIFIED
ID Code:536
Item Type:Article
Deposited On:06 Feb 2009 17:01
Last Modified:06 Feb 2009 16:01

Citation

Török, Marcel; Dzurilla, Milan; Kutschy, Peter; Imrich, Ján; Danihel, Ivan; Rademacher, Paul; Bandmann, Heinz (1994) Cyclohexylideneacetyl Isothiocyanate. Precursor for the Synthesis of 1,3-Thiazaspirocycloalkanes and 1,3-Diazaspirocycloalkanes. Collection of Czechoslovak Chemical Communications, 59 (5). pp. 1203-1210. ISSN 0010-0765

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