Preparation of 9-(2-Phosphonomethoxyethyl)adenine Esters as Potential Prodrugs

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Title:Preparation of 9-(2-Phosphonomethoxyethyl)adenine Esters as Potential Prodrugs
Creators:
Alexander, Petr
Holý, Antonín
Masojídková, Milena
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 59, 8, pp. 1853-1869

Abstract

<p>Esters of 9-(2-phosphonomethoxyethyl)adenine with substituted aliphatic alcohols were prepared as potential prodrugs. Activation of the phosphonate moiety with dimethylchloromethyleneammonium chloride, generated by reaction of thionyl chloride or triphosgene with dimethylformamide, proved to be the method of choice. The esters were also prepared by alkylation of the phosphonate group with dimethylformamide dialkyl acetals or a mixture of the appropriate alcohol with dimethylformamide dineopentylacetal.

Title:Preparation of 9-(2-Phosphonomethoxyethyl)adenine Esters as Potential Prodrugs
Creators:
Alexander, Petr
Holý, Antonín
Masojídková, Milena
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:59
Number:8
Page Range:pp. 1853-1869
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19941853UNSPECIFIED
ID Code:609
Item Type:Article
Deposited On:06 Feb 2009 17:02
Last Modified:06 Feb 2009 16:02

Citation

Alexander, Petr; Holý, Antonín; Masojídková, Milena (1994) Preparation of 9-(2-Phosphonomethoxyethyl)adenine Esters as Potential Prodrugs. Collection of Czechoslovak Chemical Communications, 59 (8). pp. 1853-1869. ISSN 0010-0765

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