Electrochemical behavior of disopyramide and its adsorptive stripping determination in pharmaceutical dosage forms and biological fluids

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Title:Electrochemical behavior of disopyramide and its adsorptive stripping determination in pharmaceutical dosage forms and biological fluids
Creators:
Öztürk, Funda
Taşdemir, Ibrahim Hüdai
Durmuş, Zehra
Kiliç, Esma
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 75, 6, pp. 685-702
Uncontrolled Keywords:Human urine, Square wave cathodic adsorptive stripping voltammetry, Electron transfer, Human serum, Adsorption, Hanging mercury drop electrode, Disopyramide, Pharmaceuticals, Voltammetry, Electrochemistry

Abstract

Electrochemical behavior of disopyramide (DPA) and optimum conditions to its quantitative determination were investigated using voltammetric methods. Some electrochemical parameters such as diffusion coefficient, surface coverage of adsorbed molecules, electron transfer coefficient, standard rate constant and number of electrons were calculated using the results of cyclic and square-wave voltammetry. All studies were based on the quasi-reversible and adsorption-controlled electrochemical reduction signal of DPA at about –1.60 V vs Ag|AgCl at pH 10.0 in Britton–Robinson buffer. This adsorptive character of molecule was used to develop fully validated, new, rapid, selective and simple square-wave cathodic adsorptive stripping voltammetric (SWCAdSV) method to the direct determination of DPA in pharmaceutical dosage forms and biological samples without time-consuming steps prior to drug assay. Peak current of electrochemical reduction of DPA was found to change linearly with the concentration in the range from 7.15 × 10<sup>–8</sup> mol l<sup>–1</sup> (0.024 mg l<sup>–1</sup>) to 1.43 × 10<sup>–6</sup> mol l<sup>–1</sup> (0.49 mg l<sup>–1</sup>). Limit of detection (LOD) and limit of quantification (LOQ) were found to be 5.65 × 10<sup>–8</sup> mol l<sup>–1</sup> (0.019 mg l<sup>–1</sup>) and 1.88 × 10<sup>–7</sup> mol l<sup>–1</sup> (0.064 mg l<sup>–1</sup>), respectively. The method was successfully applied to assay the drug in tablets, human serum and human urine with good recoveries at about 100%.

Title:Electrochemical behavior of disopyramide and its adsorptive stripping determination in pharmaceutical dosage forms and biological fluids
Creators:
Öztürk, Funda
Taşdemir, Ibrahim Hüdai
Durmuş, Zehra
Kiliç, Esma
Uncontrolled Keywords:Human urine, Square wave cathodic adsorptive stripping voltammetry, Electron transfer, Human serum, Adsorption, Hanging mercury drop electrode, Disopyramide, Pharmaceuticals, Voltammetry, Electrochemistry
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:75
Number:6
Page Range:pp. 685-702
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc2010010UNSPECIFIED
ID Code:6184
Item Type:Article
Deposited On:11 Oct 2010 13:53
Last Modified:11 Oct 2010 11:53

Citation

Öztürk, Funda; Taşdemir, Ibrahim Hüdai; Durmuş, Zehra; Kiliç, Esma (2010) Electrochemical behavior of disopyramide and its adsorptive stripping determination in pharmaceutical dosage forms and biological fluids. Collection of Czechoslovak Chemical Communications, 75 (6). pp. 685-702.

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