Acyclic Nucleoside and Nucleotide Analogs Derived from 2-Azaadenine

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Title:Acyclic Nucleoside and Nucleotide Analogs Derived from 2-Azaadenine
Creators:
Hocková, Dana
Masojídková, Milena
Buděšínský, Miloš
Holý, Antonín
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 60, 2, pp. 224-236

Abstract

<p>Alkylation of cesium salt of 2-azaadenine with appropriate synthons afforded the following acyclic analogs of nucleosides and nucleotides: (<i>S</i>)-9-(2,3-dihydroxypropyl)-2-azaadenine (<i>VI</i>), 3-(2-azaadenin-9-yl)-2-hydroxypropanoic acid (<i>VIII</i>), 9-(2-phosphonomethoxyethyl)-2-azaadenine (<i>Xb</i>), (<i>R</i>)-9-(2-phosphonomethoxypropyl)-2-azaadenine (<i>XIb</i>) and (<i>S</i>)-9-(3-hydroxy-2-phosphonomethoxypropyl)-2-azaadenine (<i>XVIb</i>). In some cases the N-2 isomers were also isolated.

Title:Acyclic Nucleoside and Nucleotide Analogs Derived from 2-Azaadenine
Creators:
Hocková, Dana
Masojídková, Milena
Buděšínský, Miloš
Holý, Antonín
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:60
Number:2
Page Range:pp. 224-236
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19950224UNSPECIFIED
ID Code:712
Item Type:Article
Deposited On:06 Feb 2009 17:03
Last Modified:06 Feb 2009 16:03

Citation

Hocková, Dana; Masojídková, Milena; Buděšínský, Miloš; Holý, Antonín (1995) Acyclic Nucleoside and Nucleotide Analogs Derived from 2-Azaadenine. Collection of Czechoslovak Chemical Communications, 60 (2). pp. 224-236. ISSN 0010-0765

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