Synthesis of Nitro-Substituted 4-Oxo-4H-pyrimido[2,1-b]benzothiazole-3-carboxylic Acids and Their Spectral Characteristics

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Title:Synthesis of Nitro-Substituted 4-Oxo-4H-pyrimido[2,1-b]benzothiazole-3-carboxylic Acids and Their Spectral Characteristics
Creators:
Bartovič, Alexander
Ilavský, Dušan
Šimo, Ondrej
Zalibera, Lubomír
Belicová, Anna
Seman, Milan
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 60, 4, pp. 583-593

Abstract

<p>The Gould-Jacobs reaction of all position isomeric 2-aminonitrobenzothiazoles II with diethyl ethoxy- methylenemalonate has been studied. The structure of substitution (<i>IV</i>) and cyclization (<i>VI</i>) products and of the corresponding acids (VIII) was confirmed by elemental analysis, IR, UV, <sup>1</sup>H and <sup>13</sup>C NMR spectra. Analogous derivatives <i>III</i>, <i>V</i> and <i>VII</i>, derived from the unsubstituted 2-aminobenzothiazole <i>I</i>, were used as standards in interpretation of the spectra. The synthesized derivatives <i>I</i> - <i>VIII</i> were tested for antimicrobial activity.

Title:Synthesis of Nitro-Substituted 4-Oxo-4H-pyrimido[2,1-b]benzothiazole-3-carboxylic Acids and Their Spectral Characteristics
Creators:
Bartovič, Alexander
Ilavský, Dušan
Šimo, Ondrej
Zalibera, Lubomír
Belicová, Anna
Seman, Milan
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:60
Number:4
Page Range:pp. 583-593
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19950583UNSPECIFIED
ID Code:747
Item Type:Article
Deposited On:06 Feb 2009 17:03
Last Modified:06 Feb 2009 16:03

Citation

Bartovič, Alexander; Ilavský, Dušan; Šimo, Ondrej; Zalibera, Lubomír; Belicová, Anna; Seman, Milan (1995) Synthesis of Nitro-Substituted 4-Oxo-4H-pyrimido[2,1-b]benzothiazole-3-carboxylic Acids and Their Spectral Characteristics. Collection of Czechoslovak Chemical Communications, 60 (4). pp. 583-593. ISSN 0010-0765

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