Synthesis and Biological Activity of Four Vasopressin Analogs Modified in Position 3 with β-Thienylalanine

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Title:Synthesis and Biological Activity of Four Vasopressin Analogs Modified in Position 3 with β-Thienylalanine
Creators:
Slaninová, Jiřina
Czaja, Malgorzata
Lammek, Bernard
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 60, 4, pp. 681-686

Abstract

<p>Four new analogs of arginine-vasopressin substituted in position 3 with β-thienylalanine were synthesized on chloromethylated resin using Boc strategy and DCC or DCC-HOBt to form peptide bonds. The activity of the agonists is not much different in comparison to the unsubstituted compounds. However, the potency of one of the antagonists is strongly reduced.

Title:Synthesis and Biological Activity of Four Vasopressin Analogs Modified in Position 3 with β-Thienylalanine
Creators:
Slaninová, Jiřina
Czaja, Malgorzata
Lammek, Bernard
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:60
Number:4
Page Range:pp. 681-686
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19950681UNSPECIFIED
ID Code:756
Item Type:Article
Deposited On:06 Feb 2009 17:03
Last Modified:06 Feb 2009 16:03

Citation

Slaninová, Jiřina; Czaja, Malgorzata; Lammek, Bernard (1995) Synthesis and Biological Activity of Four Vasopressin Analogs Modified in Position 3 with β-Thienylalanine. Collection of Czechoslovak Chemical Communications, 60 (4). pp. 681-686. ISSN 0010-0765

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