Substituted 1-(2-Thienyl)cyclohexylamines and Related Compounds as Potential NMDA Antagonists

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Title:Substituted 1-(2-Thienyl)cyclohexylamines and Related Compounds as Potential NMDA Antagonists
Creators:
Šindelář, Karel
Dobrovský, Karel
Krejčí, Ivan
Polívka, Zdeněk
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 60, 5, pp. 894-902

Abstract

<p>Reactions of bisulfite addition compounds prepared in situ from cyclohexanone or 3,4,5,6-tetrahydro-2<i>H</i>-thiopyran-3-one with potassium cyanide and corresponding amines resulted with high yields in amino nitriles type of <i>V</i> and <i>VI</i>. These compounds were subjected to reactions with 2-thienylmagnesium bromide and in the case of the amino nitriles <i>Vc</i> and <i>Vf</i> with 5-bromo-2-thienylmagnesium bromide. Only in the case of compound <i>Vf</i>, a by-product <i>X</i> was isolated in addition to the desired 1-[1-(5-bromo-2-thienyl)-1-cyclohexyl]piperidine (<i>VIIf</i>). Compound <i>VIIf</i> was used for the synthesis of the carboxylic acid <i>XI</i>. The compounds prepared were tested by some methods of biochemical and behavioural pharmacology.

Title:Substituted 1-(2-Thienyl)cyclohexylamines and Related Compounds as Potential NMDA Antagonists
Creators:
Šindelář, Karel
Dobrovský, Karel
Krejčí, Ivan
Polívka, Zdeněk
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:60
Number:5
Page Range:pp. 894-902
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19950894UNSPECIFIED
ID Code:780
Item Type:Article
Deposited On:06 Feb 2009 17:03
Last Modified:06 Feb 2009 16:04

Citation

Šindelář, Karel; Dobrovský, Karel; Krejčí, Ivan; Polívka, Zdeněk (1995) Substituted 1-(2-Thienyl)cyclohexylamines and Related Compounds as Potential NMDA Antagonists. Collection of Czechoslovak Chemical Communications, 60 (5). pp. 894-902. ISSN 0010-0765

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