Study of Relationship Between Surface Anaesthesia and Chromatographic Properties of Alkoxy Esters of Phenylcarbamic Acid by Neural Network Method. Part I.

[img]PDF - Authorized users only
Language: English
68Kb
Title:Study of Relationship Between Surface Anaesthesia and Chromatographic Properties of Alkoxy Esters of Phenylcarbamic Acid by Neural Network Method. Part I.
Creators:
Hatrík, Štefan
Lehotay, Jozef
Čižmárik, Jozef
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 60, 6, pp. 960-965

Abstract

<p>The advanced mathematical method of neural network was employed for studying of surface anaesthetical activity of three homologous series of 2-, 3- and 4-alkoxy substituted morpholinoethyl, piperidinoethyl and azepanylethyl esters of phenylcarbamic acids. RP-HPLC capacity factors were used for the characterization of the lipophility of tested drugs and they were included to the neural network. The three-layer perceptron, that is trained by the back propagation of errors was successfully used for the supplementing of the incomplete original data matrix and also for the smoothing of the noisy biological data. The dependencies between the surface anaesthesia and the number of C atoms in the side alkoxy chain presented the peak character which is in agreement with the theoretical assumptions. Surface anaesthesia grew up in order from <i>para</i> to <i>ortho</i> position of alkoxy chain (<i>para &lt; meta &lt; ortho</i>) in individual homologous series. The azepanyl derivatives presented in average the highest surface anaesthesia. This fact is in agreement with the lowest polarity of azepanyl substituent.

Title:Study of Relationship Between Surface Anaesthesia and Chromatographic Properties of Alkoxy Esters of Phenylcarbamic Acid by Neural Network Method. Part I.
Creators:
Hatrík, Štefan
Lehotay, Jozef
Čižmárik, Jozef
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:60
Number:6
Page Range:pp. 960-965
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19950960UNSPECIFIED
ID Code:788
Item Type:Article
Deposited On:06 Feb 2009 17:04
Last Modified:06 Feb 2009 16:04

Citation

Hatrík, Štefan; Lehotay, Jozef; Čižmárik, Jozef (1995) Study of Relationship Between Surface Anaesthesia and Chromatographic Properties of Alkoxy Esters of Phenylcarbamic Acid by Neural Network Method. Part I. Collection of Czechoslovak Chemical Communications, 60 (6). pp. 960-965. ISSN 0010-0765

Repository Staff Only: item control page