Quantitative Relationships Between Structure, Aggregation Properties and Antimicrobial Activity of Quaternary Ammonium Bolaamphiphiles

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Title:Quantitative Relationships Between Structure, Aggregation Properties and Antimicrobial Activity of Quaternary Ammonium Bolaamphiphiles
Creators:
Pavlíková, Magdaléna
Lacko, Ivan
Devínský, Ferdinand
Mlynarčík, Dušan
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 60, 7, pp. 1213-1228

Abstract

<p>QSAR analysis employing Kubinyi's bilinear model was applied to examine the relationship between the structure (characterized by the lengths of the terminal hydrocarbon chain, <i>m</i>, and of the hydrocarbon spacer chain, <i>y</i>), lipophilicity (characterized by the chromatographic parameter <i>R<sub>m</sub></i> and aggregation properties expressed through the critical micellar concentration <i>c</i><sub>K</sub>), and antimicrobial activity (characterized by the minimum inhibition concentration, MIC) of quaternary ammonium bolaamphiphiles. The log <i>c</i><sub>K</sub> = <i>f</i>(<i>m</i>) dependence was found to be linear whereas the log (1/MIC) = <i>f</i>(<i>m</i>), log (1/MIC) = <i>f</i>(<i>y</i>), log (1/MIC) = <i>f</i> (log <i>c</i><sub>K</sub>) and log (1/MIC) = <i>f</i>(<i>R<sub>m</sub></i>) dependences were nonlinear. The effect of the hydrophobic terminal chains (<i>m</i>) and of the hydrophobic spacer chain (<i>y</i>) on the aggregation properties and on the biological activity of the substances was studied.

Title:Quantitative Relationships Between Structure, Aggregation Properties and Antimicrobial Activity of Quaternary Ammonium Bolaamphiphiles
Creators:
Pavlíková, Magdaléna
Lacko, Ivan
Devínský, Ferdinand
Mlynarčík, Dušan
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:60
Number:7
Page Range:pp. 1213-1228
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19951213UNSPECIFIED
ID Code:818
Item Type:Article
Deposited On:06 Feb 2009 17:04
Last Modified:06 Feb 2009 16:04

Citation

Pavlíková, Magdaléna; Lacko, Ivan; Devínský, Ferdinand; Mlynarčík, Dušan (1995) Quantitative Relationships Between Structure, Aggregation Properties and Antimicrobial Activity of Quaternary Ammonium Bolaamphiphiles. Collection of Czechoslovak Chemical Communications, 60 (7). pp. 1213-1228. ISSN 0010-0765

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