Synthesis and Antituberculotic Activity of Some Substituted 3-Arylamino-5-cyano-2-pyrazinecarboxamides

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Title:Synthesis and Antituberculotic Activity of Some Substituted 3-Arylamino-5-cyano-2-pyrazinecarboxamides
Creators:
Doležal, Martin
Hartl, Jiří
Lyčka, Antonín
Buchta, Vladimír
Odlerová, Želmíra
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 60, 7, pp. 1236-1241

Abstract

<p>Nucleophilic substitution of 3-chloro-5-cyano-2-pyrazinecarboxamide by substituted anilines afforded substituted 3-arylamino-5-cyano-2-pyrazinecarboxamides <i>I-X</i>. The structures of compounds were confirmed by elemental analysis, UV, IR and <sup>1</sup>H NMR spectra. The assessment of in vitro antimycotic and antimycobacterial activities of the compounds was carried out. The highest antituberculotic activity against <i>M. tuberculosis</i> in this series was shown by 3-anilino- 5-cyano-2-pyrazinecarboxamide (<i>I</i>), whose efficacy was the same as that of pyrazinecarboxamide.

Title:Synthesis and Antituberculotic Activity of Some Substituted 3-Arylamino-5-cyano-2-pyrazinecarboxamides
Creators:
Doležal, Martin
Hartl, Jiří
Lyčka, Antonín
Buchta, Vladimír
Odlerová, Želmíra
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:60
Number:7
Page Range:pp. 1236-1241
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19951236UNSPECIFIED
ID Code:820
Item Type:Article
Deposited On:06 Feb 2009 17:04
Last Modified:06 Feb 2009 16:04

Citation

Doležal, Martin; Hartl, Jiří; Lyčka, Antonín; Buchta, Vladimír; Odlerová, Želmíra (1995) Synthesis and Antituberculotic Activity of Some Substituted 3-Arylamino-5-cyano-2-pyrazinecarboxamides. Collection of Czechoslovak Chemical Communications, 60 (7). pp. 1236-1241. ISSN 0010-0765

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