Synthesis of Monomeric 2-[(2-Methyl-2-propenoyl)oxy]ethyl Esters of Prostaglandins

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Title:Synthesis of Monomeric 2-[(2-Methyl-2-propenoyl)oxy]ethyl Esters of Prostaglandins
Creators:
Paleček, Jaroslav
Veselý, Ivan
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 60, 7, pp. 1242-1246

Abstract

<p>This paper describes a new synthesis of monomeric 2-/(2-methyl-2-propenoyl)oxy/ethyl esters of prostaglandins (<i>IIa</i>-<i>IId</i>). The monomeric esters were prepared by reaction of an alkali metal or triethylammonium salt of a prostaglandin of the F<sub>2a</sub> or A<sub>2</sub> series (<i>Ia</i>-<i>Id</i>) with 2-iodoethyl (<i>IIIa</i>) or 2-bromoethyl-2-methyl-2-propenoate (<i>IIIb</i>) in good to high yields. These monomers have been used for preparing reversible anchoring of prostaglandins on a modified three-dimensional biocompatible hydrogels prepared by copolymerization with 2-hydroxyethyl 2-methyl-2-propenoate. The application of functionalized polymers could be used in drug forms with controlled liberation of biologically active PG derivatives.

Title:Synthesis of Monomeric 2-[(2-Methyl-2-propenoyl)oxy]ethyl Esters of Prostaglandins
Creators:
Paleček, Jaroslav
Veselý, Ivan
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:60
Number:7
Page Range:pp. 1242-1246
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19951242UNSPECIFIED
ID Code:821
Item Type:Article
Deposited On:06 Feb 2009 17:04
Last Modified:06 Feb 2009 16:04

Citation

Paleček, Jaroslav; Veselý, Ivan (1995) Synthesis of Monomeric 2-[(2-Methyl-2-propenoyl)oxy]ethyl Esters of Prostaglandins. Collection of Czechoslovak Chemical Communications, 60 (7). pp. 1242-1246. ISSN 0010-0765

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