Synthesis of Poly(ethylene glycol) Block Copolymers as Potential Water-Soluble Drug Carriers

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Title:Synthesis of Poly(ethylene glycol) Block Copolymers as Potential Water-Soluble Drug Carriers
Creators:
Pechar, Michal
Strohalm, Jiří
Ulbrich, Karel
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 60, 10, pp. 1765-1780

Abstract

<p>The synthesis of a model water-soluble drug carrier based on poly(ethylene glycol) (PEG) block copolymers is described. In the copolymers, two blocks of PEG are linked by a biodegradable oligopeptide or amino acid linkage containing the glutamic acid residue. 4-Nitroaniline as a drug model is attached to the γ-carboxyl group of glutamic acid of the polymer carrier via an enzymatically degradable oligopeptide spacer. The oligopeptides used were potential substrates for chymotrypsin. The relationship between the structure of oligopeptides linking two PEG blocks and the rate of chymotrypsin-catalyzed polymer chain degradation as well as the relationship between the structure of the spacer and kinetics of drug model release from the carrier after incubation in chymotrypsin solution is discussed in detail. The results showed that by modifying the structure of oligopeptides in the polymer construct, changes in the rates of both polymer degradation and the drug model release can be achieved in a very broad range.

Title:Synthesis of Poly(ethylene glycol) Block Copolymers as Potential Water-Soluble Drug Carriers
Creators:
Pechar, Michal
Strohalm, Jiří
Ulbrich, Karel
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:60
Number:10
Page Range:pp. 1765-1780
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19951765UNSPECIFIED
ID Code:869
Item Type:Article
Deposited On:06 Feb 2009 17:04
Last Modified:06 Feb 2009 16:04

Citation

Pechar, Michal; Strohalm, Jiří; Ulbrich, Karel (1995) Synthesis of Poly(ethylene glycol) Block Copolymers as Potential Water-Soluble Drug Carriers. Collection of Czechoslovak Chemical Communications, 60 (10). pp. 1765-1780. ISSN 0010-0765

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