QSAR Study on Antibacterial Effects of Benzimidazole and Imidazopyridine Derivatives

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Title:QSAR Study on Antibacterial Effects of Benzimidazole and Imidazopyridine Derivatives
Creators:
Özden, Seçkin
Ertepinar, Hamide
Geban, Ömer
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 60, 12, pp. 2178-2188

Abstract

<p>A set of benzimidazole (<i>I</i>) and imidazopyridine (<i>II</i>) derivatives previously tested for their antibacterial activities against <i>Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), Escherichia coli (E. coli)</i>, and <i>Bacillus subtilis (B. subtilis)</i> were analyzed by quantitative structure-activity relationship (QSAR) and the activity contributions for structural and substituent effects were determined using multiple regression procedure. The resulting QSAR revealed that for the activity contribution against <i>S. aureus</i> and <i>P. aeruginosa</i> the substituents of <i>p</i>-position on the phenyl moiety play important role, and besides the <i>p</i>-substituents the substituents in other positions improve the activity. For the potency against <i>E. coli</i>, the character of six membered ring of the fused ring system becomes important besides the substituents effects at the <i>p</i>-position of the phenyl group. It was also found that both the benzimidazole ring system and <i>p</i>-substituted benzyl moiety have significant structural effects besides the lipophilicity of the substituents at R<sup>3</sup> for the activity against <i>B. subtilis</i>.

Title:QSAR Study on Antibacterial Effects of Benzimidazole and Imidazopyridine Derivatives
Creators:
Özden, Seçkin
Ertepinar, Hamide
Geban, Ömer
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:60
Number:12
Page Range:pp. 2178-2188
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19952178UNSPECIFIED
ID Code:907
Item Type:Article
Deposited On:06 Feb 2009 17:04
Last Modified:06 Feb 2009 16:05

Citation

Özden, Seçkin; Ertepinar, Hamide; Geban, Ömer (1995) QSAR Study on Antibacterial Effects of Benzimidazole and Imidazopyridine Derivatives. Collection of Czechoslovak Chemical Communications, 60 (12). pp. 2178-2188. ISSN 0010-0765

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